Friday, August 31, 2012

Step Up Your Parenting Online game With One Of These Useful ...

Raising a kid is difficult work, without any level of advice or prep may change that. Preparation and knowledge may have an impact, though, on the effects that challenging parenting function provides. A valuable idea with the perfect time may make the parenting process much simpler. Continue reading to get a few ideas that may fix some youngster-rearing difficulties.

Soon after adopting a kid, be prepared for addressing inquiries ultimately. It?s all natural for implemented young children to wonder regarding their biological families, and they may pepper you with concerns later on. As being an adoptive mother or father, make certain you are as sincere as you can in regards to the child?s biological family.

Using your toddler towards the bath room each two hours ought to take part in your potty training approach. The child might not realize how to tell you if they have to use the restroom, and often there is certainly not plenty of time and they may have an automobile accident. Visiting the bathroom constantly each number of several hours may help prevent incidents. This should support your child keep in mind.

Steer clear of interfering with your tiny child?s eating and sleeping programs when you find yourself touring. Traveling takes its toll on children, in particular infants. Sustaining exactly the same plan and rituals since you do at your home will permit your kids to compromise in her or his new surroundings, ideally permitting everybody get a lot of sleeping.

Create a written listing of guidelines that your kids have to comply with. They need to also know you will see effects to breaking those principles. Children succeed when their environment is actually a structured one. Developing such an atmosphere requires that these principles and outcomes are obviously recognized by all. Creating precise guidelines will undoubtedly have the function of parenthood a lot more pleasurable for your complete household.

You are able to aid your kids by speaking to them about bullying. See exactly what the school?s plans will be to be sure that your youngsters know that can enable them to in the day.

You ought to never ever smoke cigarettes inside your home if you have children. In fact, this may be the time to just give up smoking to the sake of your own health insurance and your child?s. Inhaling secondhand smoking can be just as dangerous as smoking. Asthma, bronchitis, pneumonia along with other breathing disorders are much more common in children who inhale in second-hand smoke.

Setting up excellent relations having a little one as he is youthful is very important, mainly because it indicates he will be more prone to open up to you, even during these turbulent teenage years. The data that you will obtain in this post will allow you to get on your own path to developing an everlasting partnership with your youngster.

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Source: http://blog.1stfind.com/?p=508922&utm_source=rss&utm_medium=rss&utm_campaign=step-up-your-parenting-online-game-with-one-of-these-useful-information-10

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Crucial Personal Gear For Scuba Diving | TECHJAWS

Scuba diving is one of the popular leisure sports about the world. The thrill of the sport is liked by folks belonging to different age teams and in distinct elements of the world. It is important to maintain safety at all times during your underwater dive. Therefore, one needs quality personal dive equipment for scuba diving.

Personal dive gear is very important for making certain divers? safety underwater and also for their exposure protection. They help divers in underwater respiration, swimming, fighting depth-related issues and maintaining away the underwater creatures.

Some of the important personal gear equipment for scuba diving consists of the adhering to:

Masks

It really is one of the characteristic personal equipment needed for a dive. Dive masks aid in a good look at underwater and help in retaining water out of the eyes. A good see is the basic necessity for underwater dives. Masks are available in different designs and shapes. One can acquire frame much less masks, compact mask, high emphasis masks and so on. The mask typically consists of a faceplate, and a strap enclosing the nose and the head.

Snorkels

It?s an L-shaped or J-shaped snorkel utilized by snorkelers or shallow divers to breathe underwater utilizing the rubber mouthpiece fitted at the reduce end. The diver breathes fresh air from above the water floor with the use of the other open stop of the snorkel.

Boots

They are unique boots employed for dives. Also known as diving boots, these aid in supplying great fitting at the lowest surface area and also offers support during buoyancy and underwater.

Fins

Swim fin, fins or perhaps flippers are important for swimming or moving in water. Whether the individual is swimming or diving under the water, fins aid in their movement in water. They are employed by scuba divers and sports persons for water sports this sort of as swimming, browsing, knee boarding and so on. They are produced in the shape of real fins and provide the exact same support to divers and swimmers.

Gloves

Scuba diving gloves are unique gloves that do not permit water to come in contact with the divers? palms. The gloves are of distinct types; namely, cotton gloves, moist gloves and dry gloves. In general, these gloves offer protection against water although they do not offer any thermal protection.

For more information, go to Buceo as well as Scuba Diving

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Source: http://www.techjaws.net/crucial-personal-gear-for-scuba-diving/

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Sudan rebels call for aid through S. Sudan, Ethiopia

Rebels in Sudan's war-torn South Kordofan and Blue Nile states, where hundreds of thousands of people have been affected by fighting, called Wednesday for aid to be sent in through South Sudan and Ethiopia.

The request -- which the rebels said they will formally make next week -- comes as an international aid plan falls behind schedule despite warnings about the humanitarian situation in the two states along Sudan's southern border.

"We will ask for the cross-border operation from South Sudan and Ethiopia," Arnu Ngutulu Lodi, spokesman for the rebel Sudan People's Liberation Movement-North (SPLM-N), told AFP.

He said the Sudanese government "is not respecting" a memorandum of understanding signed on August 5.

A ruling party official in Khartoum, however, insisted the government is committed to providing humanitarian assistance to all those affected by the war.

Both the government and rebels signed similar memorandums with the African Union, Arab League and UN to allow for humanitarian access throughout South Kordofan and Blue Nile -- including in rebel-held areas.

The signing came six months after the three organisations submitted their proposal to Khartoum.

The UN has expressed concern for months about a worsening humanitarian situation in the war zone, where Khartoum cited security concerns in tightly restricting the operations of foreign aid agencies.

Lodi accused the government of "delaying tactics" and said the rebels would officially request the cross-border operation at a meeting between the signatories next Tuesday.

He said the rebels are still "committed to the MOU" and to working with the three foreign organisations.

Ali Adam, a director general of Sudan's Humanitarian Aid Commission, confirmed on Monday that implementation of the memorandum was behind schedule. He said the required planning meetings had not yet occurred.

"Our duty and our responsibility is to provide aid to our people in South Kordofan and Blue Nile," Rabbie Abdelatti Ebaid, a senior official of the ruling National Congress Party, told AFP. "Each and every and all support will be provided by our government."

Under the memorandum reached between Khartoum, the UN, AU and Arab League, the "entire humanitarian operations" are to be under Sudanese government supervision.

A United Nations source said the UN "has to respect the sovereignty of nation states" and could not enter a country without its permission.

But the source, declining to be named, said the UN "does understand why some humanitarian organisations, seeing what is happening... may wish to pursue" a cross-border operation.

"We will continue to work with the government to facilitate humanitarian assistance into SPLM-North areas under the memorandum of understanding that was signed with the tripartite," the UN source told AFP.

Ethnic minority insurgents of the SPLM-N were allies of southern rebels during Sudan's 22-year civil war, which ended in a 2005 peace deal and South Sudan's independence in July last year.

Sudan accuses South Sudan of supporting the SPLM-N, a charge which analysts believe despite denials by the government in Juba.

"We are not acknowledging the so-called northern sector of SPLM," Ebaid said.

The UN says more than 650,000 people have been displaced or severely affected by the fighting in South Kordofan and Blue Nile, where related conflicts began in June and September last year.

Government figures showed that more than 8,700 were uprooted in the latest fighting which continued this week around Al Moreib village in northeastern South Kordofan.

The rebels said on Friday that the government "campaign" against civilian areas aimed to stymie the international aid plan.

In total, more than 160,000 refugees have fled to South Sudan from South Kordofan and Blue Nile, the UN says.

In mid-August, the UN's World Food Programme began rare air drops of food to the refugees in South Sudan, calling the move "a sign of the increasing urgency" with much of the area inaccessible because of flooding.

Source: http://news.yahoo.com/sudan-rebels-call-aid-sudan-ethiopia-153601726.html

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Thursday, August 30, 2012

Home Improvement: Landscaping Outdoor Decorating | Affordable ...

[unable to retrieve full-text content][waw_video video="Ceg4_gElhAg" hoplink="http://zebeelou.SOMALLC.hop.clickbank.net/"] A? 7250 Landscaping Ideas & Landscape Designs ? Backyard Landscaping Ideas Pictures ? Home Garden, Front Yard Landscape ...

Source: http://affordabledisneyfamilytrip.aquasunestates.com/1415/home-improvement-landscaping-outdoor-decorating/

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Why publishers don't like Apps | Kuwait Times

?NEW YORK: By the time Apple released the iPad in April of 2010, only four months after Steve Jobs first announced his ?magical and revolutionary? new machines, traditional publishers were gripped by a collective delusion. They had convinced themselves that tablet computers and smart phones would allow them to unwind their unhappy histories with the Internet.

For publishers whose businesses had evolved during the long day of print newspapers and magazines, the expansion of the Internet was terribly disorienting. The Web taught readers that they might read stories whenever they liked without charge, and it offered companies more efficient ways to advertise; both parties spent less. Yorker?s editors gushed: ?This latest technology ? provides the most material at the most advanced stage of digital speed and capacity. It has everything that is in the print edition and more: extra cartoons, extra photographs, videos, audio of writers and poets reading their work. This week?s inaugural tablet issue features an animated version of David Hockney?s cover, which he drew on an iPad.? Giddiest of all was the chief executive of News Corp., Rupert Murdoch: he lavished $30 million on the launch of The Daily, an experimental iPad-only newspaper with a $39.99 subscription price.

Smart phones and tablets seemed to promise a return to simpler days. It was true that digital replicas of print newspapers and magazines (most often read inside Web browsers) had never been very popular, but publishers reasoned that reading replicas on desktop computers and laptops was an unpleasant experience. The forms of the new smart devices were a little like those of magazines or newspapers. Couldn?t publishers delight readers by delivering something similar to existing digital replicas but suitably enhanced with interactive features? They told themselves that the new digital replicas would be better than their Web-bound kin because they would run in ?native? applications on mobile operating systems like Apple?s iOS, and thus would possess the dazzling functions of true software.

For traditional publishers, the scheme was alluring. Because they were once again delivering a discrete product, analogous to a newspaper or magazine, they could charge readers for single-copy sales and subscriptions, re?ducating audiences that journalism was something valuable for which they must pay. Software vendors like Adobe promised that editorial created with their print-oriented copy-management systems could be ?seamlessly? transferred to the apps. And as for software development ? well, how hard was that? Most publishers had Web-development departments: let the nerds build the apps.

Publishers also expected to revive the old print advertising economy. The Audit Bureau of Circulations (ABC), the industry organization that audits circulation and audience information for magazines and newspapers in North America, said the replicas inside apps would count toward ?rate base,? the measure of publications? total circulation, which includes subscription and newsstand sales. Rate base had been the metric for setting advertising rates in publishing before the emergence of online banner and keyword advertising, where electronic arcana like click-throughs and ad impressions are the accepted currencies. Apps would return media to its proper, historical structure: publishers could sell digital versions of the same ads that appeared in their print publications (perhaps with a markup if the ad had interactive elements), valued with the old measurement of rate base.

People lost their heads. One symptom of the industry?s euphoria was a brief-lived literary genre, the announcement of the iPad edition. In late 2010, the New

Unpacked in this fashion, the delusion is clear enough, but I succumbed myself-at least a little. I never believed that apps would unwind my industry?s disruption, but I felt that some readers would want a beautifully designed digital replica of Technology Review on their mobile devices, and I bet that our developers could create a better mobile experience within applications. I liked the idea of bundling inside an app all the editorial we produced, including the daily news and video we post to TechnologyReview.com. So we created iOS and Google Android apps that were free to download: anyone could read our daily news or watch our videos without charge, but they had to pay to see digital replicas of the magazine.

We launched the platforms in January of 2011. Complimenting myself on my conservatism, I budgeted less than $125,000 in revenue in the first year. That meant fewer than 5,000 subscriptions and a handful of single-issue sales. Easy, I thought. What could go wrong?

Like almost all publishers, I was badly disappointed. What went wrong? Everything.

Apple demanded a 30 percent vigorish on all single-copy sales through its iTunes store. While publishers were accustomed to handing over as much as 50 percent to newsstand distributors, the depth of the cut smarted because it was unexpected; many publishers responded by not selling single copies in Apple?s store. Then, for a year after the launch of the iPad, Apple couldn?t work out how to sell subscriptions in a way that satisfied ABC, which requires publishers to record ?fulfillment? information about subscribers. When Apple finally solved the problem of transferring fulfillment data to publishers, it again claimed its 30 percent share. That hurt more than the vig on single-issue sales: publishers have always hated sharing subscription revenues with third parties, a business they associate with shady resellers who traffic in notoriously disloyal readers. Starting in June of last year, Apple did allow publishers to directly fulfill subscriptions through their own Web pages (a handful of publishers, including Technology Review, had enjoyed the privilege earlier), but the mechanism couldn?t match iTunes for ease of use. Google was more reasonable in its terms, but Android never emerged as a significant alternative to the iPad: today, most tablet computers are still Apple machines.

There were other difficulties. It turned out that it wasn?t at all simple to adapt print publications to apps. A large part of the problem was the ratio of the tablets: they possessed both a ?portrait? (vertical) and ?landscape? (horizontal) view, depending on how the user held the device. Then, too, the screens of smart phones were much smaller than those of tablets. Absurdly, many publishers ended up producing six different versions of an editorial product: a print publication, a conventional digital replica for Web browsers and proprietary software, a digital replica for landscape viewing on tablets, something that was not quite a digital replica for portrait viewing on tablets, a kind of hack for smart phones, and ordinary HTML pages for their websites.
Software development of apps was much harder than publishers had anticipated, because they had hired Web developers who knew technologies like HTML, CSS, and JavaScript. Publishers were astonished to learn that iPad apps were in fact real, if small, applications, written mostly in a language called Objective C, which no one in their Web-dev departments knew. Publishers responded by outsourcing app development, which was expensive, time-consuming, and unbudgeted.

But the real problem with apps was more profound. When people read news and features on electronic media, they expect the stories to possess the linkyness of the Web-but stories in apps didn?t really link. The apps were, in the jargon of information technology, ?walled gardens,? and although sometimes beautiful, they were small and stifling. For readers, none of the novelty or prettiness of apps overcame the weirdness and frustration of reading digital media closed off from other digital media.

The Daily?s fortunes were not atypical: the publication has found only 100,000 subscribers, well short of the half-million Rupert Murdoch said would be necessary to make it a viable business. The gloom was general. With few subscribers and single-copy buyers, there were no audiences to sell to advertisers, and therefore no revenues to offset the incremental costs of app development. Most publishers soured on apps.

The most commonly cited exception to the general bitterness is Cond? Nast, which saw its digital sales increase by 268 percent last year after Apple introduced an iPad app called Newsstand. Still, even 268 percent growth may not be saying much in total numbers: digital is a small business for Cond? Nast. Wired magazine, among the most digital of Cond? Nast?s titles, had 33,237 digital-only subscriptions last year, representing just 4.1 percent of a total circulation of 812,434, and 7,004 digital single-copy sales, which is 0.8 percent of paid circulation, according to ABC. (Wired spins the numbers differently, claiming a digital circulation of 108,622; but that sum includes the 68,380 print subscribers who activated free digital access.) Similarly, the New Yorker, another Cond? Nast publication, last year had only 26,880 digital-only subscribers among its million subscribers.

Today, most owners of mobile devices read news and features on publishers? websites, which have often been coded to adapt themselves to smaller screens. Or, if they do use apps, the apps are glorified RSS readers, such as Google Reader, Flipboard, and the apps of newspapers like , which grab editorial from the publisher?s site. A recent Nielsen study reported that while 33 percent of tablet and smart-phone users had downloaded news apps in the previous 30 days, just 19 percent of users had paid for any of them. Apps are good for plenty of things: you can use them to translate street signs in a foreign city, or discover the cheapest bulk source of floor wax, or, if you?re carefree and so inclined, hook up with willing partners. But the paid, expensively developed publisher?s app, with its extravagantly produced digital replica, is increasingly uncommon.

?The recent history of the Financial Times is instructive. Last June, the company pulled its iPad and iPhone app from iTunes and launched a new version of its website written in HTML5, which can optimize a site for any device and provide features and functions that are app-like. For a few months, the FT continued to support the iPad and iPhone app, but on May 1, the paper chose to kill it altogether.

?And Technology Review? We sold 353 subscriptions through the iPad. We never discovered how to avoid the necessity of designing both landscape and portrait versions of the magazine for the app. We wasted $124,000 on outsourced software development, a sum that does not begin to capture our allocation of internal resources. We fought among ourselves, and people left the company. There was untold expense of spirit. I hated every moment of our experiment with apps, because it tried to impose something closed, old, and print-like on something open, new, and digital.

?Last fall, in version 3.0 of our apps, we moved the editorial content, including the magazine, into simple RSS feeds in ?rivers of news.? We dumped the digital replica altogether. Now we?re redesigning ?TechnologyReview.com, which we have made free to use, and we?ll follow the Financial Times in using HTML5, so that our Web pages will look great on a laptop or desktop, tablet, or smart phone. Then we?ll kill our apps, too. Now we just need to discover how to make the Web pay. ? MCT

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Source: http://news.kuwaittimes.net/2012/08/28/why-publishers-dont-like-apps/

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Monday, August 27, 2012

PUMA Squash 2000 Sneakers

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Iran opens nonaligned summit with nuclear appeals

An expert-level meeting of the Non-Aligned Movement, NAM, takes place in Tehran, Iran, Sunday, Aug. 26, 2012. Iran opened a world gathering of self-described nonaligned nations Sunday with a slap at the vast powers of the U.N. Security Council and an appeal to rid the world of nuclear weapons even as Tehran faces Western suspicions that it is seeking its own atomic arms. Iran seeks to use the weeklong gathering as a showcase of its global ties and efforts to challenge the influence of the West and its allies. (AP Photo/Vahid Salemi)

An expert-level meeting of the Non-Aligned Movement, NAM, takes place in Tehran, Iran, Sunday, Aug. 26, 2012. Iran opened a world gathering of self-described nonaligned nations Sunday with a slap at the vast powers of the U.N. Security Council and an appeal to rid the world of nuclear weapons even as Tehran faces Western suspicions that it is seeking its own atomic arms. Iran seeks to use the weeklong gathering as a showcase of its global ties and efforts to challenge the influence of the West and its allies. (AP Photo/Vahid Salemi)

Iranian Foreign Minister Ali Akbar Salehi delivers a speech to an expert-level meeting of the Non-Aligned Movement, NAM, in Tehran, Iran, Sunday, Aug. 26, 2012. Iran opened a world gathering of self-described nonaligned nations Sunday with a slap at the vast powers of the U.N. Security Council and an appeal to rid the world of nuclear weapons even as Tehran faces Western suspicions that it is seeking its own atomic arms. Iran seeks to use the weeklong gathering -- capped by a two-day summit of various leaders -- as a showcase of its global ties and efforts to challenge the influence of the West and its allies. (AP Photo/Vahid Salemi)

Damaged cars that three Iranian scientists, Masoud Ali Mohammadi, right, Majid Shahriari, center, and Mostafa Ahmadi Roshan, were riding in when they were killed in bombings over the last three years are displayed outside a conference hall hosting the meeting of Non-Aligned Movement, NAM, in Tehran, Iran, Sunday, Aug. 26, 2012. Iran says the attacks against its scientists are part of a covert campaign by Israel and the West to sabotage its nuclear program, which the U.S. and its allies suspect is aimed at producing nuclear weapons. Posters show some of the slain scientist's children who were not killed. (AP Photo/Vahid Salemi)

Arab diplomats talk prior to the start of an expert-level meeting of the Non-Aligned Movement, NAM, in Tehran, Iran, Sunday, Aug. 26, 2012. Iran opened a world gathering of self-described nonaligned nations Sunday with a slap at the vast powers of the U.N. Security Council and an appeal to rid the world of nuclear weapons even as Tehran faces Western suspicions that it is seeking its own atomic arms. Iran seeks to use the weeklong gathering as a showcase of its global ties and efforts to challenge the influence of the West and its allies. (AP Photo/Vahid Salemi)

Iran's envoy to the International Atomic Energy Agency, IAEA, Ali Asghar Soltanieh, left, talks with a foreign diplomat prior to the start of an expert-level meeting of the Non-Aligned Movement, NAM, in Tehran, Iran, Sunday, Aug. 26, 2012. Iran opened a world gathering of self-described nonaligned nations Sunday with a slap at the vast powers of the U.N. Security Council and an appeal to rid the world of nuclear weapons even as Tehran faces Western suspicions that it is seeking its own atomic arms. Iran seeks to use the weeklong gathering as a showcase of its global ties and efforts to challenge the influence of the West and its allies. (AP Photo/Vahid Salemi)

(AP) ? Iran opened a world gathering of self-described nonaligned nations Sunday with a slap at the U.N. Security Council and an appeal to rid the world of nuclear weapons, even as Tehran faces Western suspicions that it is seeking its own atomic bombs.

Iran seeks to use the weeklong gathering ? capped by a two-day summit of Non-Aligned Movement leaders ? as a showcase of its global ties and efforts to challenge the influence of the West and its allies. Among those expected to attend include U.N. Secretary-General Ban Ki-moon and the prime minister of India, Manmohan Singh, whose nation remains an important Iranian oil customer as Tehran battles Western sanctions over its nuclear program.

The 120-nation Non-Aligned Movement, a holdover from the Cold War's pull between East and West, is also seen by Iran and others as an alternative forum for current world discussions. Iran says it plans talks on a peace plan to end Syria's civil war, but no rebel factions will attend because of Tehran's close bonds with Syrian President Bashar Assad's regime.

Iranian Foreign Minister Ali Akbar Salehi opened the gathering by noting commitment to a previous goal from the nonaligned group, known as NAM, to remove the world's nuclear arsenals within 13 years.

"We believe that the timetable for ultimate removal of nuclear weapons by 2025, which was proposed by NAM, will only be realized if we follow it up decisively," he told delegates.

Iran insists it does not seek nuclear weapons. The U.S. and allies suspect that Tehran's uranium enrichment could eventually lead to warhead-level material. They have imposed ever-tighter sanctions on Iran's banking and oil exports in attempt to wring concessions.

Israel has said that it would consider military options if diplomacy and economic pressures fail to curb Iran's nuclear ambitions.

Salehi criticized Israel for remaining outside the U.N. main treaty governing the spread of nuclear technology. Israel refused to discuss the full range of its military capabilities, but it is widely believed to have a nuclear arsenal.

Iran ally North Korea has withdrawn from the Nuclear Non-Proliferation Treaty. North Korean Foreign Minister Pak Ui Chun arrived in Tehran Sunday to attend the meetings.

Outside the meeting site, Iran displayed three cars damaged by bomb blasts that Iran has blamed on agents from Britain, the U.S. and Britain. At least five members of Iranian scientific community, including nuclear experts, have been killed since early 2010 as part of a suspected covert war with its main foes.

Iran and proxies, in turn, have been linked by investigators to a series of attacks and plots on Israeli targets around the world.

Salehi also complained about the perception of the "falling" clout of the U.N.'s general membership at the expense of the "rising power of the U.N. Security Council," led by permanent members U.S., Britain, France, Russia and China.

"Creating a more democratic Security Council should be considered an important part of U.N. reforms," Salehi told the gathering.

Even before the first session got under way, however, a dispute flared over Palestinian envoys.

Iranian officials said a political leader of Tehran's ally Hamas has not been invited to the meeting in Tehran, contradicting Hamas claims that Prime Minister Ismail Haniyeh was asked to come by Iranian President Mahmoud Ahmadinejad. Hamas later Sunday that Haniyeh has dropped plans to attend.

The decision appeared aimed at avoiding a confrontation among Palestinians that could embarrass Hamas' Iranian backers. The office of Palestinian President Mahmoud Abbas had warned he would not attend if rival Haniyeh also takes part.

The militant Hamas controls Gaza, while Abbas' Western-backed administration governs parts of the West Bank. Abbas' Foreign Minister Riad Malki also plans to travel to Tehran on Monday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-08-26-ML-Iran-Nonaligned-Summit/id-03164b89e11e493ab79eb1dda18f7489

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Venezuela: refinery to restart in two days after fire

PARAGUANA, Venezuela (Reuters) - Venezuela's biggest refinery is on track to restart within two days, the energy minister said on Sunday, a day after an explosion and fire there killed 39 people in one of the global oil industry's deadliest accidents.

Energy Minister Rafael Ramirez said the fire was now contained in two storage tanks, reiterating that no production units had been affected by Saturday's pre-dawn disaster at the 645,000-barrel-per-day (bpd) Amuay refinery, which sits on a peninsula in the Caribbean in western Venezuela.

On Sunday, the skeletal remains of a National Guard barracks destroyed in the blast sagged amid broken concrete and rubble, amid flames and huge plumes of smoke coming from the two burning tanks, which contained naphtha and crude oil.

The explosion flattened some homes in the immediate vicinity, in some cases just across the street from the refinery's fence. Nearby roads were covered with petroleum.

The victims included 18 National Guard troops and 15 civilians; six remain unidentified.

Reuters witnesses said firefighters did not appear to be trying to extinguish the blaze just before midday on Sunday, suggesting that the authorities may have decided to let the remaining fuel in the tanks burn itself out.

The accident, which also wounded dozens of people, was the worst to hit Venezuela's oil industry. It follows a decade of repeated outages and accidents at installations run by state oil company PDVSA that have prompted allegations of mismanagement by President Hugo Chavez's government.

But the incident is likely to have little impact on world fuel prices because Venezuela can use its existing fuel stocks to supply the South American country's domestic market, as well as maintain exports.

It ranks as one of the deadliest refinery accidents in the recent history of the global oil industry, approaching the toll of the 1997 fire at Hindustan Petroleum's Visakhapatnam refinery in India that killed 56, and topping the 2005 BP Texas City refinery blast that killed 15 workers.

Amuay had already partially shut operations at least twice this year due to a small fire and the failure of a cooling unit.

Venezuela has traditionally been a key supplier of fuel to the United States, but U.S. reliance on the OPEC nation has declined sharply over the last five years due in part to repeated unplanned outages at Venezuelan refineries.

SECOND-BIGGEST COMPLEX

In the first five months of 2012, the United States imported just over 50,000 bpd of fuel from Venezuela, down from nearly 290,000 bpd in 2005, according to data from the U.S. Energy Information Administration. Venezuela still ranks among one of the top five suppliers of crude oil to the United States.

Amuay, together with a neighboring facility, forms part of the Paraguana Refining Center, the second-biggest refinery complex in the world, with an overall capacity of 955,000 bpd. Only India's Jamnagar complex is bigger, at 1.24 million bpd.

(Additional reporting by Matthew Robinson in New York; Writing by Brian Ellsworth; Editing by Daniel Wallis and Cynthia Osterman)

Source: http://news.yahoo.com/venezuela-refinery-restart-two-days-fire-154428456.html

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iPhone 4S Discount At Radio Shack - Business Insider

RadioShack is slashing $75 off the price of a 16 GB iPhone 4S starting tomorrow, reports The Verge.

You'll be able to scoop up a new phone for just $125, a major discount off of the usual $200 price tag.

Keep in mind that this is all in light of the new iPhone launching next month -- buying a new phone now would lock you into a contract for a while and you'd just be a spectator for the iPhone 5 launch.

But if you don't care about being on the cutting edge, you can't do much better than this.

Please follow SAI: Tools on Twitter and Facebook.
Follow Dylan Love on Twitter.

Tags: Phones, Apple, Discounts | Get Alerts for these topics ?

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'; } else if (google_ads.length > 1) { /* * For text ads, append each ad to the string. */ for(i = 0; i

Source: http://www.businessinsider.com/iphone-4s-discount-at-radio-shack-2012-8

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Sunday, August 26, 2012

Romney reaches out to women before GOP convention

TAMPA, Fla. (AP) ? Mitt Romney said it is "sad" that President Barack Obama's campaign is trying to link him to Rep. Todd Akin's statements about abortion, as top Republicans preparing for the party's nominating convention urged the GOP presidential challenger to reach out to women and Hispanics.

The remarks came Sunday as Republicans descending on Florida prepared to cram four days of events into three because of the threat caused by the approach of Tropical Storm Isaac.

Romney said that as Massachusetts governor, he had helped women by guaranteeing coverage for them ? and men as well ? by enacting that state's health care coverage legislation. Romney has pledged that as president he would repeal Obama's health care overhaul law ? which is similar to the Massachusetts statute ? but Romney said he was proud of that accomplishment.

Akin is the GOP Missouri Senate candidate who said women's bodies have ways of avoiding pregnancy after a "legitimate" rape. Romney and other GOP leaders have criticized those statements and urged Akin to drop out of the Senate race.

Asked in an interview broadcast Sunday on "Fox News Sunday" about Obama campaign efforts to link Akin's remarks to Romney and other Republicans, Romney said, "It really is sad, isn't it, with all the issues that America faces for the Obama campaign to continue to stoop to such a low level."

Romney said the controversy over Akin "hurts our party and I think is damaging to women."

Meanwhile, Sen. John McCain, R-Ariz., said Romney must sell his message to women and Hispanics if he is to oust Obama in the November elections.

Speaking on NBC's "Meet the Press," the former GOP presidential candidate said Romney must convince women and Hispanics that "jobs and the economy are more important perhaps than other issues."

Former Florida GOP Gov. Jeb Bush had a similar message about the Hispanic vote, saying on NBC, "Governor Romney can make inroads if he focuses on how do we create a climate of job creation and economic growth."

Bush, who has long urged his party to craft a more conciliatory message to Hispanics, added, "We've got to have a better tone going forward over the long haul for sure. You can't ask people to join your cause and then send a signal that 'you're really not wanted.' It just doesn't work."

Blue skies with patches of clouds hung over Tampa early Sunday, though winds were picking up as the major storm approached.

As aides in Tampa scramble, Romney is taking a rare day off the campaign trail at his lakeside vacation home in New Hampshire, receiving updates on the storm and making final preparations for the Thursday speech with which he will accept his party's presidential nomination.

"The safety of those in Isaac's path is of the utmost importance," Romney tweeted after Republican officials announced they had called off Monday's convention proceedings.

Because of possible storm surges and flooding Isaac could bring, convention organizers said they were making contingency plans to move delegates who have been booked into beachfront hotels to other locations if necessary. They indicated the schedule shift also was meant to prevent overburdening emergency response personnel at the height of the storm.

The GOP made the announcement late Saturday, saying that while the convention would officially be gaveled into session on Monday as scheduled, events would be postponed until Tuesday.

Convention spokesman James Davis said organizers were closely monitoring the storm's path but planned to rely on emergency management officials to guide decisions on whether to relocate delegates at waterfront hotels. So far, none have been moved nor had officials received word of major problems for inbound delegates.

Davis said the GOP's advice to delegates was "if your travel plans have not been interrupted and they're set, we recommend you come on down."

With Isaac boring down on the coast, President Barack Obama, who had been at Camp David presidential retreat in Maryland, dispatched the Federal Emergency Management Agency to establish a command center and move more resources into the state. Vice President Joe Biden scrapped a planned campaign trip into Florida that was to counter the start of the GOP convention.

Republicans hope to use this week's convention to cast Romney as a determined leader with the know-how to fix the country's economy. They also want to introduce him as a family oriented figure to counter the image of him as a ruthless businessman as Democrats have sought to brand him.

While the Romneys reveled in their convention, Obama was due to travel next week to college towns in Iowa, Colorado and Virginia to court young voters and college students. The president's nomination for a desired second term was to come a week later in Charlotte, N.C., during a Democratic convention beginning Sept. 4, right on the heels of the Republican convention.

In an interview with The Associated Press published Saturday, Obama sought to portray Romney as someone beholden to "extreme positions" on economic and social issues. Obama took pains to paint Romney and his running mate, Wisconsin Rep. Paul Ryan, as ideologues at a time when voters seem frustrated by government gridlock.

After a near-constant travel schedule since he was announced as the GOP vice presidential candidate, Ryan was also taking a rare break. Following a Saturday evening fundraiser in Manchester, N.H., he returned home to Janesville, Wis. Aides said Ryan planned a quiet Sunday. Then, before flying to Florida, he was to appear at a Monday rally in his hometown that was likely to offer him a hero's sendoff.

A few of Romney's former presidential rivals were holding events of their own in Tampa. Herman Cain and Minnesota Rep. Michele Bachmann ? both have endorsed Romney ? were appearing at a joint event. Texas Rep. Ron Paul, who hasn't conferred his blessing on the presumptive nominee, was anticipating thousands at a University of South Florida rally.

___

Associated Press writers Philip Elliott and Steve Peoples in New Hampshire and Ken Thomas in Washington contributed to this report.

Source: http://news.yahoo.com/romney-reaches-women-gop-convention-141832836.html

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Mom's Viewpoint: If you don't know, phone a friend | Gay Salt Lake ...

by Leesa Myers

When my son, Jay, told me he was gay, I knew he was uncomfortable with me asking him questions. I really wanted to be sensitive to his feelings, but I didn?t know exactly what it meant to be gay. I had questions.? I had a friend I had known for several years who was gay. I knew I could ask him anything and he would be straightforward with me.? I called Mike when I got home from my evening with Jay.? I told Mike that Jay had told me he was gay; he asked how I felt.

?I am OK with it, I am just sad that Jay didn?t feel safe enough to tell me until now. ?I really want to know what you went through and what is it to be gay.?

Mike told me he had a hard time telling his parents and still to this day his parents are not comfortable with his sexuality, even though they say they have accepted him. Mike came from a strong Catholic family. In fact, he and his family thought that one day he would be a priest.

But he had a long and powerful relationship which brought him to Utah. When his partner broke up with him, it was devastating.? He went into self-destruct mode. He began binge eating and became very promiscuous, avoiding relationships, looking for men to have sex which took him to his lowest of lows. He eventually found a 12-step program and changed his life.

I asked Mike about being gay, he said, ?Everyone?s mind immediately goes to sex and how two men can have sex together.?? Mike put it very bluntly, which I wanted.

?We are not doing anything that your husband has not asked you to do in the privacy of your own bedroom,? he said.

He went on to explain that a relationship is more than that for you and for me or anyone.? It?s about being intimate, it?s about loving, sharing and caring and building a life with the one you love.? We want the same things, to have a life with a partner, to have a family, to be accepted and to be loved for ourselves. Mike said I could call him anytime and if Jay needed help he could call his ?auntie Mikey? too.

I left that conversation understanding that Jay is going to have the same experiences of dating, of getting hurt, wanting to build a relationship and have a family just like any straight man or woman. I can support Jay as I do his sister in her struggles, pains and triumphs.

It was good to talk with Mike; even today I have many great friends that are gay, lesbian and transgender that I can call and ask questions and get advice.? Jay and I have built a stronger relationship since he told me that he?s gay, we are able to talk openly and he also has brought me literature to read.

What I learned is that if I want help I can ask friends and that there are a lot of resources available too.? Here are some resources that can help if you are looking for answers: utahpridecenter.org, equalityutah.org, community.pflag.org, hrc.org, gaysaltlake.org/directory and Coming Out to Parents by Mary V. Borhek.

Leesa Myers is a positive change consultant and can be reached at Leesa@LeesaMyers.com and leesamyers.com.

Source: http://gaysaltlake.com/2012/08/25/moms-viewpoint-if-you-dont-know-phone-a-friend/

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Thursday, August 23, 2012

HP has $8.9B loss on expected charge for EDS flop

SAN FRANCISCO (AP) ? Hewlett-Packard absorbed the largest quarterly loss in its history as the Silicon Valley pioneer owned up to past mistakes that have left it scrambling to adapt to a shifting technology market.

The loss of $8.9 billion announced Wednesday didn't come as a surprise. HP telegraphed the news earlier this month when it disclosed plans to take an $8 billion charge to reflect the shrinking value of Electronic Data Systems, a technology consulting service it bought for $13 billion in 2008.

It represented another mortifying setback for a 73-year-old company that once had the reputation for being a fountain of innovation ?and a great place to work, to boot. Now, HP is struggling to reverse perceptions that it's becoming a technological dinosaur bogged down in bureaucracy as it slashes its work force to help offset a downturn in revenue.

The company is counting on Meg Whitman, its third CEO in slightly more than two years, to be its savior. While stressing she believes HP can still be great again, Whitman made it clear Wednesday that it will be a long slog.

"Make no mistake about it: We are still in the early stages of a turnaround," Whitman told analysts during a conference call.

That has become Whitman's mantra since HP hired her as CEO 11 months ago. Later in the call, Whitman acknowledged "the very serious execution issues" facing HP as it tries to catch up to its rivals and cope with a weakening economy, particularly in Europe.

Whitman, who became one of the world's best-known chief executives during a decade-long stint running eBay Inc., has been shaking things up at HP by reorganizing divisions, ushering in new managers and slashing costs through the job cuts.

As Whitman's remarks underscored the enormity of the challenge facing HP, more investors bailed out of the company's stock. HP shares sank 94 cents, or nearly 5 percent, to $18.26 in Wednesday's after-hours trading, reversing earlier gains after the latest quarterly results were released. The shares have lost more than half their value in the past two years, a factor that contributed the EDS charge during the three-month period ending in July.

HP also had to absorb charges to cover severance payments for the first wave of the 27,000 workers it is jettisoning to dramatically reduce its expenses as its revenue shrivels. The company, which is based in Palo Alto, Calif., now expects to drop 11,500 employees from its payroll by the end of October, up from its previous target of 9,000. Another 15,500 employees will be let go through October 2014.

The cutbacks are driven by the rising popularity of mobile phones and tablet computers ? devices that are reducing demand for personal computers. That's bad news for HP, which is the world's largest maker of PCs and printers.

To cope with the upheaval, HP has been expanding into technology consulting, computer software, data storage and high-end servers made for companies and government agencies. All those specialties are more profitable than the fiercely competitive PC market, but HP hasn't been evolving rapidly enough to avoid an alarming deterioration in its financial performance.

Like several other major technology companies, HP has also been hurt by the recent economic turmoil in Europe. The uncertainty caused by unwieldy government debt in Europe has curbed spending on the continent.

If HP's slump worsens, management warned it may have to register additional charges in the current quarter to account for trouble in other acquisitions. Without citing specifics, HP executives pointed to the company's software operations as one area that could be lumped with a major accounting charge. That division includes Autonomy, a business software service that HP bought for $11 billion last year.

The fiscal third-quarter loss Wednesday translates to $4.49 per share for a period covering the three months ending in July. The company earned $1.9 billion, or 93 cents per share, at the same time last year.

HP's revenue sank 5 percent from last year to $29.7 billion. That was about $500 million below the projections of analysts polled by FactSet. It marked HP's fourth consecutive year-over-year quarterly decrease in revenue.

PC sales during the latest quarter fell by about 10 percent from the same time last year, Whitman said. She traced the decline to fierce price competition, a growing preference for tablet computers and smartphones, and postponed purchases among buyers waiting for the release of a new line of machines running Windows 8, a radical overhaul of Microsoft Corp.'s operating system set for release October 26.

Whitman's clampdown on expenses also appeared to be delivering savings more quickly than Wall Street anticipated. If not for the company's various charges, HP said it would have earned $1 per share. That figure was 2 cents per share above analyst estimates.

Source: http://news.yahoo.com/hp-8-9b-loss-expected-charge-eds-flop-203303602--finance.html

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Read This Article Before Investing In Real Estate | Wordy Writing

Dealing with the commercial real estate business can be overwhelming and stressful for beginners as well as those who have already been through it before. In this article that follows you can learn some good advice to apply to your ventures when it comes to commercial real estate, in order to relieve some stress off your shoulders.

Size is highly important when you are searching for space for your growing business. Try to invest into a commercial property which has room to grow to avoid shopping in just a few years again.

Before you jump into a commercial real estate deal, you want to get a lay of the land first. This means considering and examining the general income levels in the area, how high or low unemployment rates are, and looking at the hiring practices of employers within the vicinity of where you intend to invest. If you?re house is close to a university, hospital, or large employment center, they sell quick and at increased values.

When purchasing property, look at the amount of units available. The more units you have, the easier you can spread out the wealth you are receiving from each of them. A lot of people who invest in real estate do not even give consideration to properties that contain fewer than ten units. It is generally accepted that a higher number of units correlates to higher profits.

Writing a blog on the Internet, ideally on your own website, is a great way to prove your expertise to others. This assists in locating people to buy or lease your property.

Location is the most important factor in choosing a commercial property to buy. When investing in a property, consider what type of neighborhood it is located in. You will also want to calculate growth expectations by comparing similar neighborhoods. Make sure that the area will still be nice and growing in several years.

Tackling different mediums is advised, such as sending a more monthly set in a real estate newsletter, while keeping smaller, daily posts on your preferred social networking solution. Do not fade away in the online world once you have completed a deal.

Use a digital camera to take pictures. Include all the defects in the photo, such as carpet stains, or holes in the walls.

When selling commercial property, advertise locally and outside of your region. A lot of people do not think that people from out of town will want to buy their commercial real estate. There are many private investors who would purchase property outside of their local area if the price is right.

When you?re writing letters of intent, try to keep it brief by agreeing with the bigger issues initially and let the lesser issues be resolved at a later time. This approach lowers the overall tension level and actually makes it easier to reach agreement on the details at the end.

If you are looking to invest in an apartment complex, be mindful of the fact that smaller communities can pose more complexity than dealing with a larger one. Due to this, a lot of field experts advise avoiding any property with a single digit number of units. Don?t take this as a hard-and-fast rule, though. Your research might reveal that a five-unit property is a true gem.

Be sure to only focus on one investment at a time. For example, you may choose to work mostly with apartment complexes, strip malls, undeveloped land or restaurants. Learn more about all the different types of investment to make good decisions. Becoming a guru in one investment category is preferable to minimal success spread across multiple investments.

If you are signing a commercial real estate lease, be hesitant if you are asked to sign a standard lease form. Some real estate firms will add questionable requirements to these documents, and because of the length of these leases such additions are often overlooked. By carefully perusing the document, you?ll avoid potential headaches and heartaches that a commercial lease sometimes produces.

Regardless of whether you are new to commercial property dealings or a seasoned professional, the act of seeking just the right deal can be very stressful. This article can help make your search for commercial property less

Tags: general income levels, preferred social networking solution, hard-and-fast rule, five-unit property, higher number, different mediums

Source: http://wordywriting.com/read-this-article-before-investing-in-real-estate/

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Wednesday, August 22, 2012

Johns Hopkins researchers return blood cells to stem cell state

Johns Hopkins researchers return blood cells to stem cell state [ Back to EurekAlert! ] Public release date: 22-Aug-2012
[ | E-mail | Share Share ]

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Johns Hopkins scientists have developed a reliable method to turn the clock back on blood cells, restoring them to a primitive stem cell state from which they can then develop into any other type of cell in the body.

The work, described in the Aug. 8 issue of the journal Public Library of Science (PLoS), is "Chapter Two" in an ongoing effort to efficiently and consistently convert adult blood cells into stem cells that are highly qualified for clinical and research use in place of human embryonic stem cells, says Elias Zambidis, M.D., Ph.D., assistant professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.

"Taking a cell from an adult and converting it all the way back to the way it was when that person was a 6-day-old embryo creates a completely new biology toward our understanding of how cells age and what happens when things go wrong, as in cancer development," Zambidis says.

"Chapter One," Zambidis says, was work described last spring in PLoS One in which Zambidis and colleagues recounted the use of this successful method of safely transforming adult blood cells into heart cells. In the latest experiments, he and his colleagues now describe methods for coaxing adult blood cells to become so-called induced-pluripotent stem cells (iPS) --- adult cells reprogrammed to an embryonic like state, and with unprecedented efficiencies.

Zambidis says his team has managed to develop a "super efficient, virus-free" way to make iPS cells, overcoming a persistent difficulty for scientists working with these cells in the laboratory. Generally, out of hundreds of blood cells, only one or two might turn into iPS cells. Using Zambidis' method, 50 to 60 percent of blood cells were engineered into iPS cells.

Zambidis' team also found a way around the use of viruses to convert the cells to a stem cell state. Traditionally, scientists use viruses to deliver a package of genes to cells to turn on processes that convert the cells from one type (such as skin or blood) back to stem cell states. However, viruses used in this way can mutate genes and initiate cancers in newly transformed cells. To insert the genes without using a virus, Zambidis' team uses plasmids, rings of DNA that replicate briefly inside cells and then degrade. The blood cells were also given an additional new step in which they were stimulated with their natural bone-marrow environment.

For the new study, the Johns Hopkins team took cord blood cells, treated them with growth factors, and used plasmids to transfer four genes into them. They then delivered an electrical pulse to the cells, making tiny holes in the surface through which the plasmids could slip inside. Once inside, the plasmids triggered the cells to revert to a more primitive cell state. The scientific team next grew some of the treated cells in a dish alone, and some together with irradiated bone-marrow cells.

When scientists compared the cells grown using the blood cell method with iPS cells grown from hair cells and from skin cells, they found that the most superior iPS cells came from blood stem cells treated with just four genes and cultured with the bone marrow cells. These cells converted to a primitive stem cell state within seven to 14 days. Their techniques also were successful in experiments with blood cells from adult bone marrow and from circulating blood.

In ongoing studies, Zambidis and colleagues are testing the quality of the newly formed iPS cells and their ability to convert to other cell types, as compared with iPS cells made by other methods.

Efficient methods to produce virus-free iPS cells may speed research to develop stem cell therapies, using nearly all cell types, and may provide a more accurate picture of cell development and biology.

###

The study's co-authors were Tea Soon Park, Jeffrey S. Huo, Ann Peters, C. Conover Talbot Jr., Karan Verma, Ludovic Zimmerlin, and Ian M. Kaplan. The work was supported by grants from the National Heart, Lung, and Blood Institute, (1U01HL099775 and U01HL100397), the National Cancer Institute (CA60441), both part of the National Institutes of Health, and the Maryland Stem Cell Research Fund (2011-MSCRF II-0008-00 and 2007-MSCRF II-0379-00).

Links:

The Zambidis Laboratory at Johns Hopkins http://www.hematopoiesis.org/Zambidis/Home.html

Public Library of Science http://www.plos.org/



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Johns Hopkins researchers return blood cells to stem cell state [ Back to EurekAlert! ] Public release date: 22-Aug-2012
[ | E-mail | Share Share ]

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Johns Hopkins scientists have developed a reliable method to turn the clock back on blood cells, restoring them to a primitive stem cell state from which they can then develop into any other type of cell in the body.

The work, described in the Aug. 8 issue of the journal Public Library of Science (PLoS), is "Chapter Two" in an ongoing effort to efficiently and consistently convert adult blood cells into stem cells that are highly qualified for clinical and research use in place of human embryonic stem cells, says Elias Zambidis, M.D., Ph.D., assistant professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.

"Taking a cell from an adult and converting it all the way back to the way it was when that person was a 6-day-old embryo creates a completely new biology toward our understanding of how cells age and what happens when things go wrong, as in cancer development," Zambidis says.

"Chapter One," Zambidis says, was work described last spring in PLoS One in which Zambidis and colleagues recounted the use of this successful method of safely transforming adult blood cells into heart cells. In the latest experiments, he and his colleagues now describe methods for coaxing adult blood cells to become so-called induced-pluripotent stem cells (iPS) --- adult cells reprogrammed to an embryonic like state, and with unprecedented efficiencies.

Zambidis says his team has managed to develop a "super efficient, virus-free" way to make iPS cells, overcoming a persistent difficulty for scientists working with these cells in the laboratory. Generally, out of hundreds of blood cells, only one or two might turn into iPS cells. Using Zambidis' method, 50 to 60 percent of blood cells were engineered into iPS cells.

Zambidis' team also found a way around the use of viruses to convert the cells to a stem cell state. Traditionally, scientists use viruses to deliver a package of genes to cells to turn on processes that convert the cells from one type (such as skin or blood) back to stem cell states. However, viruses used in this way can mutate genes and initiate cancers in newly transformed cells. To insert the genes without using a virus, Zambidis' team uses plasmids, rings of DNA that replicate briefly inside cells and then degrade. The blood cells were also given an additional new step in which they were stimulated with their natural bone-marrow environment.

For the new study, the Johns Hopkins team took cord blood cells, treated them with growth factors, and used plasmids to transfer four genes into them. They then delivered an electrical pulse to the cells, making tiny holes in the surface through which the plasmids could slip inside. Once inside, the plasmids triggered the cells to revert to a more primitive cell state. The scientific team next grew some of the treated cells in a dish alone, and some together with irradiated bone-marrow cells.

When scientists compared the cells grown using the blood cell method with iPS cells grown from hair cells and from skin cells, they found that the most superior iPS cells came from blood stem cells treated with just four genes and cultured with the bone marrow cells. These cells converted to a primitive stem cell state within seven to 14 days. Their techniques also were successful in experiments with blood cells from adult bone marrow and from circulating blood.

In ongoing studies, Zambidis and colleagues are testing the quality of the newly formed iPS cells and their ability to convert to other cell types, as compared with iPS cells made by other methods.

Efficient methods to produce virus-free iPS cells may speed research to develop stem cell therapies, using nearly all cell types, and may provide a more accurate picture of cell development and biology.

###

The study's co-authors were Tea Soon Park, Jeffrey S. Huo, Ann Peters, C. Conover Talbot Jr., Karan Verma, Ludovic Zimmerlin, and Ian M. Kaplan. The work was supported by grants from the National Heart, Lung, and Blood Institute, (1U01HL099775 and U01HL100397), the National Cancer Institute (CA60441), both part of the National Institutes of Health, and the Maryland Stem Cell Research Fund (2011-MSCRF II-0008-00 and 2007-MSCRF II-0379-00).

Links:

The Zambidis Laboratory at Johns Hopkins http://www.hematopoiesis.org/Zambidis/Home.html

Public Library of Science http://www.plos.org/



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-08/jhm-jhr082212.php

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Curiosity rover takes first short spin around Mars

NASA scientists show a panoramic image of the Curiosity touch-down area Bradbury Landing, named after writer Ray Bradbury, showing the first tracks of the rover movements, at the Jet Propulsion Laboratory in Pasadena, Calif., Wednesday, Aug. 22, 2012. The six-wheel rover made its first test drive on Wednesday as a warm-up for the long trek to the mountain expected later this year. Shown from left: Dr. Michael Meyer, lead scientist for the Mars Exploration program at NASA Headquarters; Peter Theisinger, MSL project manger, NASA JPL, Pasadena; Matt Heverly, Lead Curiosity Driver; Roger Wiens, principal investigator of ChemCam and Joy Crisp, MSL deputy project scientist. (AP Photo/Damian Dovarganes)

NASA scientists show a panoramic image of the Curiosity touch-down area Bradbury Landing, named after writer Ray Bradbury, showing the first tracks of the rover movements, at the Jet Propulsion Laboratory in Pasadena, Calif., Wednesday, Aug. 22, 2012. The six-wheel rover made its first test drive on Wednesday as a warm-up for the long trek to the mountain expected later this year. Shown from left: Dr. Michael Meyer, lead scientist for the Mars Exploration program at NASA Headquarters; Peter Theisinger, MSL project manger, NASA JPL, Pasadena; Matt Heverly, Lead Curiosity Driver; Roger Wiens, principal investigator of ChemCam and Joy Crisp, MSL deputy project scientist. (AP Photo/Damian Dovarganes)

This Aug. 18, 2012 image provided by NASA shows the Curiosity rover's landing site and Mount Sharp in the distance. The six-wheel rover prepared to take its first test drive on Wednesday Aug. 22,2012 as a warm-up for the long trek to the mountain expected later this year. (AP Photo/NASA)

This image dated Wednesday Aug. 22, 2012 and provided by NASA shows the Curiosity rover's wheel tracks on the surface of Mars an image sent from one of the rover's cameras. The image was posted on a Tweet by JPL mission engineer Allen Chen. (AP Photo/NASA)

NASA scientists named the Curiosity touch-down area Bradbury Landing after writer Ray Bradbury, seen on screen, at the Jet Propulsion Laboratory in Pasadena, Calif., Wednesday, Aug. 22, 2012. The six-wheel rover made its first test drive on Wednesday as a warm-up for the long trek to the mountain expected later this year. Shown from left: Dr. Michael Meyer, lead scientist for the Mars Exploration program at NASA Headquarters, Peter Theisinger, MSL project manger, NASA JPL, Pasadena; Matt Heverly, Lead Curiosity Driver; Roger Wiens, principal investigator of ChemCam, and Joy Crisp, MSL deputy project scientist. (AP Photo/Damian Dovarganes)

(AP) ? Curiosity took its first test drive around the gravel-strewn Martian terrain Wednesday, preparation for the ultimate road trip to find out if the red planet's environment could have supported life.

The six-wheel NASA rover did not stray far from the spot where it landed more than two weeks ago. It rolled forward about 15 feet, rotated to a right angle and reversed a short distance, leaving track marks on the ancient soil.

Mission managers were ecstatic that the maiden voyage of the $2.5 billion mission was glitch-free.

"It couldn't be more important," said project manager Peter Theisinger at the NASA Jet Propulsion Laboratory. "We built a rover. So unless the rover roves, we really haven't accomplished anything ... It's a big moment."

The short spin came a day after Curiosity successfully wiggled its wheels to test its steering capabilities.

Curiosity landed in Gale Crater near the Martian equator Aug. 5 to explore whether the environment once supported microbial life. The touchdown site has been named Bradbury Landing in honor of the late "The Martian Chronicles" author Ray Bradbury, who would have turned 92 on Wednesday.

The rover's ultimate destination is Mount Sharp, a towering mountain that looms from the ancient crater floor. Signs of past water have been spotted at the base, which provides a starting point to hunt for the chemical building blocks of life.

Before Curiosity treks toward the mountain, it will take a detour to an intriguing spot 1,300 feet away where it will drill into bedrock. With the test drive out of the way, Curiosity was expected to stay at its new position for several days before making its first big drive ? a trip that will take as long as a month and a half.

Curiosity won't head to Mount Sharp until the end of the year.

Rover driver Matt Heverly said the first drive took about 16 minutes with most of the time used to take pictures. Heverly said the wheels did not sink much into the ground, which appeared firm.

"We should have smooth sailing ahead of us," he said.

After an action-packed landing that delicately lowered it to the surface with nylon cables, Curiosity has entered a slow streak. Since the car-size rover is the most sophisticated spacecraft sent to Mars, engineers have taken their time to make sure the rover is in tiptop shape and that its high-tech tools work before it delves into its mission.

Curiosity joins the rover Opportunity, which has been exploring craters in Mars' southern hemisphere since 2004. Opportunity's twin, Spirit, fell silent in 2010 after getting stuck in a sand trap.

Earlier this week, Curiosity exercised its robotic arm for the first time, flexing its joints and motors before engineers stowed it again. Weeks of additional tests were planned before it can drill and scoop up Martian soil.

The nuclear-powered rover has been tracking levels of dangerous radiation on the Martian surface in an effort to guide future astronaut landings. It also powered up its weather station, taking hourly readings of air and ground temperatures, pressure and wind conditions.

Over the weekend, it fired its laser at a humble rock to study what it's made of. Unsurprisingly, the zapped rock was typical of other Martian rocks, made of basalt.

During the checkups, scientists discovered a damaged wind sensor, possibly after it was hit by rocks that landed on the rover's instrument deck during landing. Deputy project scientist Ashwin Vasavada said the broken sensor will not jeopardize the mission since there's a spare.

Since nailing the daredevil landing, the rover team has been acknowledged by President Barack Obama. Gov. Jerry Brown, who declared Wednesday as "Space Day" visited the lab and donned 3-D glasses to view an animation of Curiosity's first drive on a big screen in the control room.

___

Follow Alicia Chang's Mars coverage at http://www.twitter.com/SciWriAlicia

Associated Press

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Canon imageFormula DR-C130

By M. David Stone

Similar in some ways to the Editors' Choice Canon imageFormula DR-C125 that I reviewed a few months ago, the Canon imageFormula DR-C130 offers a faster claimed speed, additional software, and a completely different physical design. As with other Canon document scanners, it stands out in particular for being able to scan, recognize text, and save to searchable PDF format just as quickly as it can scan and save to image format. That alone is enough to make it more capable than most, and worth a close look.

The most immediately obvious difference between the DR-C130 and Canon DR-C125 is the physical design. The Canon DR-C125 moves paper in a U-shaped path, with a nearly vertical output tray hugging the front of the scanner to minimize the need for desk space. The DR-C130 offers the more common approach of pushing the paper straight out, with the output tray stretching well in front of the scanner itself.

As with most desktop scanners, you can fold the tray over the scanner easily when you're not scanning, giving you a footprint of just 11.7 by 6.3 inches (WD). Open the trays, however, and you'll need roughly another eight inches of free space in front of the scanner. The input tray extends up and a few inches behind the scanner as well. The tradeoff for needing more desktop real estate for the DR-C130 than for the Canon DR-C125 is larger capacity, with a 50-page automatic document feeder (ADF).

Setup and Software
One issue that Canon scanners often have a problem with is setup. Unfortunately, the DR-C130 is even worse than most on this score. As part of the physical setup, you have to snap a roller into the unit, which is a bit of puzzle to figure out. Worse, when I removed one of the strips of shipping tape, it pulled off a plastic piece from the paper input guide, and I had to figure out how to put it back in.

The software installation suffers from problems as well. One of the supplied programs is Kofax Virtual ReScan (VRS), a highly sophisticated digital enhancement program that will let you, for example, scan highlighted text without the highlight turning into a solid black that makes the text unreadable.

VRS comes on its own installation disc, and a separate piece of paper in the box tells you that you have to install VRS before installing the Canon driver. If you overlook the piece of paper, and go by the setup guide, you won't know about that until it's too late. Also, when you install VRS, you'll find that the DR-C130 isn't on the list of certified scanners. You have to choose I will configure my scanner later and configure the program for the scanner manually instead. (Canon says that the configuration information for the DR-130 will be added to later iterations of the Kofax disc.)

Finally, for installation issues, the DR-C130, like the DR-C125, treats the applications that come with the scanner as an afterthought. The Typical option in most scanner installation routines installs everything that came with the scanner. With the DR-C130 it installs only the driver, scan utility, and user manual. The real problem, however, is that the installation screen gives no hint that there are other programs available or that you can install them only if you choose the Custom option.

Choose Custom, and you can install Nuance PaperPort 11 for document management, Nuance OmniPage SE4 for optical character recognition (OCR), NewSoft Presto! BizCard 6 SE for business cards, and Nuance eCopy PDF Pro Office for working with PDF files. You can also install an Evernote connector that lets you scan directly to Evernote. Note that most of these are either SE versions or older versions of the programs, but all are capable enough to handle most personal or small office needs.

Scan Speed and Document Management
As is the case with most document scanners, the DR-C130 offers a 600 pixel-per-inch optical (ppi) resolution, which is more than you need for scanning text. It's hard to tell what the default resolution is, however, because the default setting for the scan utility is fully automatic, with no indication of what setting it uses for each kind of document.

For my tests, I used the default settings wherever possible, which meant using the fully automatic mode for duplex scans but turning it off and changing settings manually for simplex scans. Scanning directly to image PDF files, I clocked the scanner for simplex scanning at 29.4 pages per minute (ppm), just a shade under its 30-ppm rating. For duplex scans using the default settings, however, it slowed down significantly, to 17.4 ppm and 34.9 images per minute (ipm), which is well below the 60-ipm rating (with one image on each side of the page).

Because of the large discrepancy between the measured speed and the rating, I tested again using manual settings, and wound up with close to 60 ipm. What this translates to is that the DR-C130 gives you a choice. You can have supreme simplicity with fully automatic mode or faster scans with manual mode.

As I've already mentioned, the scanner didn't slow down at all when I scanned to searchable PDF format. This is a major advantage for document management, because searchable PDF format is the preferred choice for files in most case. That, in turn, makes the DR-C130 faster in practice than other scanners with faster raw scan speed, but added time for recognizing the text.

A case in point: The Editors' Choice Kodak i2600 , hit 76.9 ipm for scanning duplex pages to image files in my tests, but it's slower than the DR-C130 (at least when using manual settings for the DR-C130) when scanning to a searchable PDF file.

Other Test Results
The DR-C130, in combination with OmniPage, also turned in a high score on our OCR test, reading both our Times New Roman and Arial test pages at sizes as small as 5 points without a mistake. It also did impressively well with some additional fonts that we always include in our testing, but rarely report results for, because most scanners do so poorly with them. In particular, it read two highly stylized fonts with thick strokes at sizes as small at 8 points without a mistake.

Unfortunately, the DR-130 didn't do well on our business card tests. The scanner feed stacks of cards well enough, but the combination of the DR-130 and BizCard made three or more mistakes on more than half of the cards, and at least one mistake on every card in our tests. It might do better with another program, but for any given program, you'd have to run tests to find out.

The scanner's problems with business cards and with both physical setup and software installation are enough to keep it from being an Editors' Choice. However, the installation issues are one-time problems, and it's highly capable in almost every other way. The speed, OCR accuracy, and ability to scan and save to searchable PDF format at top speed are all strong arguments in its favor. So is the well-chosen software package, especially with the inclusion of VRS. As long as you don't need business card recognition, the Canon imageFormula DR-C130 is a more than attractive choice.

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